The Mayflower(*) problem is this: you are the small group about to take a one-way trip to a big empty continent. What do you pack? Metaphorically.
In this metaphor, the "empty" continent is The Future,
we are being driven from our homes in the Old Country by Change undermining everything that currently works for us, and what we pack means whatever few preparations we can make now that will equip us to live in The Future...
[EDIT:] And I want to throw away the rest of that post and start over, see the comments.